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These include replicative exhaustion due to telomere shortening, DNA damage, oncogene activation, mitochondrial dysfunction, metabolic stress, proteotoxic stress, and exposure to certain inflammatory mediators or mitogens [49]

The role of polyunsaturated fatty acids in osteoarthritis: insights from a mendelian randomization study

Wegovy is FDA-approved for chronic weight management in adults and pediatric patients aged 12 years and older with obesity (BMI 30 kg/m for adults, 95th percentile for age and sex in pediatrics) or overweight (BMI 27 kg/m for adults, 85th percentile for pediatrics) with at least one weight-related comorbidity

While the gastrointestinal side effects warrant consideration, most were transient and manageable

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

While the study clarifies some conflicting findings on NVAMD risk in adults taking GLP-1s for type 2 diabetes, Cai warns that her groups findings should not be applied to other groups, such as people taking GLP-1 drugs primarily for weight loss, and additional research should be done in people without type 2 diabetes