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Following the PR sessions and 60 hour abstinence period where animals did not receive fentanyl or semaglutide, the semaglutide-experienced LgA animals completed a dose-response assessment where they received escalating doses of saline (0.9%, s.c.) and semaglutide (0.01-0.1 mg/kg s.c.) while self-administering a 2.5 g/kg/inf (i.v.) dose of fentanyl under an FR1 schedule of reinforcement

doi: 10.1186/s12199-018-0710-7 20 DaiSShuDMengFChenYWangJLiuXet al

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Semaglutide, on the other hand, is the active ingredient in the FDA-approved weight-loss medication Wegovy and the diabetes medication-turned-weight-loss-superstar Ozempic