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Some people notice mild nausea or reduced appetite within the first few hours of their initial injection, but meaningful therapeutic effects such as sustained appetite reduction and early weight changes typically develop over the first four to eight weeks as the dose is gradually escalated

Ohnishi et al., 2003

Despite a relatively short half-life of approximately 30 minutes, the peptide triggers gene expression changes that persist and cascade independently of its continued presence

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Long-term data (12 months and beyond) demonstrate that weight loss plateaus at different points for different patients

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