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GST conjugation activity GSTs have multiple biological roles, including cell protection against oxidative stress and several toxic molecules, and are involved in the synthesis and modification of leukotrienes and prostaglandins 1

Hormonal fluctuations across the menstrual cycle, pregnancy history, and the transition into perimenopause and menopause all change how the body builds muscle, stores fat, and repairs tissue

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Sedatives, alcohol, opioids, some antidepressants, antipsychotics, seizure medicines, and other sleep aids can affect alertness or breathing

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Dosage is incremented in steps over weeks, based on the body's reaction