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A randomized trial with adolescents aged 1218 years with severe obesity evaluated the efficacy of topiramate in maintaining weight loss following a 4-week meal-replacement therapy [91].There was no statistically significant difference in percent BMI change between the topiramate and placebo groups after 28 weeks

Platelet-rich fibrin (PRF) is a second-generation platelet concentrate that forms a fibrin matrix enriched with platelets, leukocytes, and growth factors, and promotes sustained tissue regeneration without the need for anticoagulants [6]

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10.1002/med.21752 Med Res Rev

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Various mechanisms contribute to the initiation and maintenance of neuropathic pain 7