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Each ampoule contains 2mg of methylcobalamin (instead of 1mg)

Side Effects Some people discontinue due to side effects like nausea, constipation, or other digestive issues

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Stimulants, SSRIs, and mood stabilizers often worsen symptoms in undermethylated children because these drugs further unbalance serotonin and dopamine pathways that are already dysregulated

Abbreviations GLP-1 RA: Glucagon-like peptide-1 receptor agonist MACE: Major adverse cardiovascular events HR: Hazard ratio CI: Confidence interval HER: Electronic health record ICD: International statistical classification of diseases and related health statistical classification of diseases and related health problems CPT: Current procedural terminology BMI: Body mass index MRA: Mineralocorticoid receptor antagonist ACE inhibitor: Angiotensin converting enzyme inhibitor ARB: Angiotensin II receptor blocker SGLT2 inhibitor: Sodium-glucose co-transporter 2 GFR: Glomerular filtration rate HbA1c: Hemoglobin A1c STROBE: Strengthening the reporting of observational studies in epidemiology SD: Standard deviation PS: Propensity score SMD: Standardized mean difference References Nichols, G