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At multiple concentrations there was hypercontractility as measured by cardiomyocyte sarcomere fractional shortening and its derivatives in response to repetitive field stimulation (Supplementary Fig

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In some instances, administration of an otic formulation or composition described herein lowers the ratio of C max to C min and provides a larger Area Under the Curve (AUC) with a prolonged PK profile based on the C min

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