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Frisoli ML, Essien K, Harris JE (2020) Vitiligo: mechanisms of pathogenesis and treatment

Pigmentation of the soles alone occurred in 25.8% of cases, whereas pigmentation isolated to the palms occurred less frequently at 7.2%

There is still limited research for this

Use a clean, dry cotton ball, or gauze pad to gently press on the injection site for a few seconds

The most consistently reported protocol is 250mcg twice daily via subcutaneous injection

This leads to the production of harmful byproducts, osmotic stress, and reactive oxygen species, causing oxidative stress, DNA damage, and endoplasmic reticulum stress