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The FDA-reviewed prescribing information for Wegovy (semaglutide 2.4 mg) discloses that in the SELECT cardiovascular outcomes trial - which enrolled adults with established cardiovascular disease - hip and pelvis fractures were reported more often in female patients on Wegovy than in those on placebo: 1% (24 of 2,448 patients) versus 0.2% (5 of 2,424 patients)

doi: 10.1038/nature01661 4 NgoSTSteynFJMcCombePA

The MDM2 inhibitor nutlin-3a suppresses abnormal T-cell expansion and reduces systemic inflammation in SLE models, highlighting an immunoregulatory role for MDM2 inhibition beyond oncology

Optimization of the nutritional status of selenium may result in higher GPx4 activity and thus delay or even prevent neuronal loss

A steady schedule can boost insulin secretion and control blood sugar levels