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Although metformin is a common drug for managing DM, however, monotherapy treatment with any antidiabetic drug will necessitate dosage increment since type 2 DM (T2DM) deteriorates over time due to the increasing pancreatic -cell dysfunction and will eventually require a combination therapy approach with another antidiabetic medication
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Due to their unique characteristics- such as wide size range, adjustable shape, and ease of modification, it is gaining more attention in the medical field, particularly for disease diagnosis and treatment[166], [167], [168], [169], [170]