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A systematic review and meta-analysis found that creatine supplementation was associated with a small but statistically significant increase in serum creatinine of approximately 0.07 micromol/L

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[DOI] [PMC free article] [PubMed] [Google Scholar] 149.No Title

This is the mechanistic reason researchers study it separately from native IGF-1: with less protein-binding interference, the analog remains bioavailable roughly 3x longer, giving it an extended half-life of approximately 2030 hours compared to native IGF-1s 1215 hours

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