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Also, chronic oxidative stress causes a buildup of misfolded proteins in the endoplasmic reticulum (ER), triggering ER stress and activating the unfolded protein response (UPR) that intensifies mucus production and contributes to the development of chronic inflammation (198200)

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Hormonal changes associated with improved metabolic health can further reduce cardiovascular disease risk

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Like other GLP-1 medications in this category, tirzepatide carries an FDA boxed warning about a possible risk of thyroid C-cell tumors, based on animal studies