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Simultaneously, the peptide inhibits enzymes involved in lipogenesis, reducing the conversion of excess calories into stored fat

Common side effects of semaglutide may include nausea, vomiting, diarrhea, and constipation

In addition, angiopoietin 2 and placental growth factor , which are associated with tumor angiogenesis, induce macrophage polarization toward the M2 phenotype, thereby leading to the development of an immunosuppressive TME 72

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