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Abbreviations A.A: Acetic acid DAI: Disease activity index DSS: Dextran sulphate sodium IBD: Inflammatory bowel disease JAK-STAT: Janus kinase/signal transducers and activators of transcription NF-B: Nuclear factor kappa B Nrf2: Nuclear factor erythroid 2related factor 2 NLRP3: Nucleotide-binding domain, leucine-richcontaining family, pyrin domaincontaining protein-3 NO: Nitric oxide synthase PPAR-: Peroxisome proliferator-activated receptor gamma TLR: Toll like receptor TNBS: 2, 4, 6-Trinitrobenzene sulfonic acid UC: Ulcerative colitis References Buie MJ, Quan J, Windsor JW, Coward S, Hansen TM, King JA, Kotze PG, Gearry RB, Ng SC, Mak JW, Abreu MT

Second, Selank modulates both dopamine and serotonin receptor activity, helping normalize the neurotransmitter imbalances that underlie depressive symptoms

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doi: 10.1016/j.bbr.2008.11.017 45

In metabolic and nutritional regulation, the GH/IGF-1 system responds dynamically to nutrient status and metabolic signals