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Nausea, vomiting, diarrhoea, constipation, and abdominal pain are experienced by a substantial proportion of patients, particularly during dose escalation

Hormone changes, especially during puberty or pregnancy, can trigger more sebum production [3]

These interactions are further complicated by metabolic conditions such as obesity and diabetes, where hormonal resistance (e.g., leptin, insulin) and neurotransmitter dysregulation contribute to altered taste preferences and compulsive eating behaviors

This could indicate dehydration (common with GI side effects), pre-existing kidney disease being unmasked, or genuine acute kidney injury

As a gastroenterologist, I regularly see patients who are unsure whether their nausea, bloating, or constipation while on these medications is normal or a sign of something more concerning

Mioduchoski, FNP-BC Insurance coverage for semaglutide and tirzepatide depends on diagnosis, medical eligibility, and individual insurance plans