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Significantly, as shown in Figure 6 in their Extended Data ( only to the inactive M pro C145A mutant, and concluded it was a likely M pro substrate, because they were able to identify a putative M pro cleavage site in the TRMT1 protein sequence (PRLQ/ANFT), where the slash (/) represents the cleavage site

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To address this, the distribution of daily oscillating genes was examined across each CM, revealing that these genes accounted for less than 30% in all CMs except CM7, where 65% of genes were identified as oscillating (Supplementary Fig

Yet clinically, the patients present as if they have some sort of systemic disorder, such as rheumatoid arthritis

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