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2,9 In contrast to other agents in the class, 7 however, early studies in animal models demonstrated that linagliptin is almost completely (99%) bound to plasma proteins (mainly the DPP-4 enzyme) at the 5 mg therapeutic concentration, perhaps because of its high binding affinity and nonpolar surface area

doi: 10.1093/bjd/ljae284 16 ShenZQChangCYYehCHLuCKHungHCWangTWet al

The antibody reacts with all the major glycoproteins present in the viral envelope and at least one core protein as determined by crossed immunoelectrophoresis

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