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In sepsis models, rmMANF exerts antioxidant effects by inhibiting the GRP78/PERK/ATF4 axis, thereby suppressing ERS-induced ferroptosis in tissues and ultimately alleviating S-ALI (Zeng et al., 2023)

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L-ferritin: one gene, five diseases

Studies have demonstrated that GLP-1 receptor activation may reduce production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1) the same inflammatory mediators that drive joint destruction in rheumatoid arthritis