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Similarly, patients with active malignancy warrant careful consideration given theoretical concerns about angiogenic effects potentially affecting tumor growth, though preclinical evidence suggests context-dependent effects that may inhibit rather than promote tumor angiogenesis

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ApoE-MiADMSA-LPS showed notable BBB penetration in in vivo imaging

No dosing errors

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Importantly, the GLP-1 response to dietary fat is vastly reduced not only in GPR40 KO animals but also in GPR119 KO mice, and agonists for the Gq-coupled GPR40 act in synergy with the Gs-coupled GPR119 to robustly stimulate GLP-1 [286,300]