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J Invest Dermatol 133:579582 Jung HJ, Kweon SS, Lee JB, Lee SC, Yun SJ (2013) A clinicopathologic analysis of 177 acral melanomas in Koreans: relevance of spreading pattern and physical stress
The characteristics of glutathione are the following: (a) discovered by Hopkins in 1921 [67], (b) synthesized intracellularly by glutamate-cysteine ligase and glutathione synthetase [68], (c) exists in reduced (GSH) and oxidized (GSSG) forms, maintaining cellular redox balance [69], (d) functions in melanogenesis inhibition through tyrosinase suppression and pheomelanin synthesis [70], and (e) oral bioavailability is enhanced through liposomal formulations, S -acetyl derivatives, or co-administration with precursors [71]
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