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As NAD+ declines, skin becomes thinner, drier, and more prone to wrinkles and damage

The study used 20 mg/kg SC three times daily in mice

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Correction of Deficiency: Reduces symptoms of B12 deficiency, which may indirectly promote weight loss

Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions