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A high concentration of single-agent AZD-5991 was needed to achieve the IC 50

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Liraglutide and the broader GLP-1 class Liraglutide, one of the earliest GLP-1 receptor agonists, has the longest track record for evaluating thyroid safety in humans

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Scientific References Khavinson VKh, Linkova NS, Kvetnoy IM, Kvetnaia TV, Polyakova VO, Korf HW (2020)