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Sperm parameters assessed included total motility, progressive motility, total static, curvilinear velocity (VCL, m/s), straight-line velocity (VSL, m/s), average path velocity (VAP, m/s), the amplitude of lateral head displacement (ALH, m), and linearity (LIN, %), Wobble (WOB, %), beat cross frequency (BCF, Hz) as defined 101

Under physiological conditions, GLP- 1 is rapidly degraded by dipeptidyl peptidase-4 (DPP- 4) after it is released ( 3 Discovery of GLP-1 In 1923, Charles Kimball and John Murlin, in an attempt to purify commercial insulin, precipitated a pancreatic fraction that had a hyperglycemic effect ( Figure 1 The proglucagon precursor ( Figure 1 4 GLP-1 receptor The GLP-1 receptor is a member of the secretin subfamily (B1) of G-protein coupled receptors (GPCRs)

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In parallel, increasing attention has focused on the gut microbiota as a regulator of host metabolism and enteroendocrine signaling

This sets the stage for everything that follows

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