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As one study explains, arginine metabolismthrough polyamine-mediated oxidative stress and impairment of antimicrobial NO synthesisleads to H

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Subsequent studies have shown that these Rho GTPases are crucial in the regulation of various aspects of cell morphology such as cell polarity and shape as well as several cellular processes such as exocytosis, endocytosis and proliferation, in a wide variety of mammalian cell types, including neurons ( Rho GTPases in Spine Formation Ample studies indicate that altering the activity of Rho GTPases can affect spinogenesis in developing neurons (Tashiro et al., 2000

But its also one of the hardest to maintain, OKAVA CEO Michael Klotsman says in the statement

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doi: 10.1007/BF01316798