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(6) Meta-analyses: A systematic review & meta-analysis found that in autistic children with cerebral folate deficiency or folate receptor alpha autoantibodies, treatment with folinic acid (leucovorin) was associated with improvements in communication, irritability, and other core symptoms

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Likewise, nowadays current clinical guidelines recognize that patients may exhibit episodes with mixed features

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GS: synthesizes glutamine from ammonia NH3, and glutamate