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All analyses were performed separately for STEP 1 and STEP 2

Samples were vortexed and, after a brief centrifugation, transferred to SureSTART 0.3 ml vials (Thermo Fisher Scientific) and fitted with SureSTART 9 mm screw caps (Thermo Fisher Scientific)

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Patients should seek urgent medical attention for any concerning chest symptoms rather than assuming they are medication-related or gastrointestinal in origin