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Moreover, experimental evidence demonstrates that calcitriol enhances the expression of multiple tight junction proteinsincluding claudin-4/7, occludin, and ZO-1via activation of PI3K/Akt and atypical PKC (aPKC) signaling pathways, thereby significantly increasing transepithelial electrical resistance (TER) and reinforcing barrier homeostasis [109]
British Journal of Clinical Pharmacology, 49(5), 423-427
First, as adjuncts to standard care, selected strains or formulationssuch as Escherichia coli Nissle 1917, VSL#3, and certain multi-strain probioticsprovide additive or synergistic benefits, improving key outcomes including clinical response, endoscopic remission, and health-related quality of life (HRQoL
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This unique ability to stimulate structural improvements in the brain positions it as a promising option for both cognitive enhancement and neuroprotection
