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Key points Key messages from the paper Incretin analogues (semaglutide, tirzepatide) provide effective glucose control in type 2 diabetes mellitus (T2DM) and major weight losses in people without diabetes

Far from being a single procedural step, a FIH trial is built on a broad body of scientific, regulatory and operational work designed to ensure that the transition from preclinical research to human investigation takes place within a rigorous framework focused on safety, quality and evidence generation

Age was used as a categorical variable, with age groups ( 45 year-old in the analysis of demographic factors associated with genotypes

Ipamorelin Ipamorelin is a growth hormone secretagogue or growth hormone-releasing peptide (GHRP)

Do not use in case of known hypersensitivity to the active substances