Tirzepatide combined with sulfonylureas also elevates risk significantly
Sadeghipour P, Jenab Y, Moosavi J, Hosseini K, Mohebbi B, Hosseinsabet A, Chatterjee S, Pouraliakbar H, Shirani S, Shishehbor MH, Alizadehasl A, Farrashi M, Rezvani MA, Rafiee F, Jalali A, Rashedi S, Shafe O, Giri J, Monreal M, Jimenez D, Lang I, Maleki M, Goldhaber SZ, Krumholz HM , Piazza G, Bikdeli B
Mazdutide functions as a balanced dual agonist of GLP-1 and glucagon receptors, designed to mimic and enhance the physiological effects of the endogenous intestinal hormone oxyntomodulin
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However, it also interacts with cardiac-specific receptors, including CD36, which may mediate its cardiovascular effects independently of GH
