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Growth factor upregulation

Drop back to the last tolerated dose and stay there for 6-8 weeks before attempting escalation again

10.3389/fphar.2022.1026182 S.Seiwerth, M

Pathogen elimination by probiotic Bacillus via signalling interference

This is particularly relevant as fatigue is a common concern during calorie restriction

Given that there is no placebo-controlled human data, no established dose, and a mechanism whose foundational papers were retracted, an absence of noticeable effect is fully consistent with the current evidence it does not necessarily indicate a defective product, the wrong route, or an insufficient duration