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It has been found that the knockout of Mfn2 leads to neurodegeneration due to oxidative stress in the brain [313]

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Mitochondrial DNA depletion and respiratory chain activity in primary human subcutaneous adipocytes treated with nucleoside analogue reverse transcriptase inhibitors

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Kunjan, F., Shanmugam, R., & Govindharaj, S

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[PMC free article: PMC4532752] [PubMed: 26268692] 624

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SS-31 (Elamipretide) targets mitochondrial cardiolipin and oxidative stress in cellular bioenergetics studies

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