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Nature Reviews Endocrinology, 8, 728-42

A person who loses 50 pounds with semaglutide plus resistance training will have a dramatically different body composition, metabolic rate, and long-term outcome than someone who loses 50 pounds with semaglutide alone

Licensed UK weight loss medicines including orlistat, semaglutide (Wegovy), and naltrexone/bupropion (Mysimba) have no established direct effect on the menstrual cycle per their UK SmPCs

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The potential relationship between GLP-1 receptor agonists like semaglutide and thyroid C-cell tumors has been observed in rodent studies, where dose-dependent and duration-dependent increases in thyroid C-cell tumors were noted

For many in the UK, this struggle is not just about aesthetics