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Although holding in farts can worsen digestive symptoms and cause discomfort, it shouldnt have any long-term implicationsas long as the gas eventually escapes, one way or another

Because experimental drugs targeting acid ceramidase are already in development for other clinical applications, these findings provide an immediate framework for developing therapeutics to extend human healthspan

However, the specific mechanisms underlying these responses remain to be investigated

10.3945/ajcn.111.013458

Cancer Chemother Pharm