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Berberine , a plant alkaloid that lowers blood glucose and cholesterol through AMPK and is often called natures metformin, has no clinical evidence for cognition or neuroprotection, only animal work

This likely reflects the additive gastrointestinal effects of combining two separate appetite-suppressing compounds

Potential Side Effects Though B12 shots are largely safe, some may experience: Mild pain or redness at the injection site Headache Swelling Diarrhea Itchy skin rash Conclusion As we journey through health and wellness trends, Vitamin B12 shots stand out, not as a fad, but a testament to the importance of this crucial nutrient

The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A

FDA advisory meeting page US Food and Drug Administration

Heres how the injections can help, though