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Emerging therapeutic strategies focus on reducing AGEs accumulation to alleviate PCOS symptoms
The immune system produces autoantibodies against nuclear components (DNA, histones, ribosomes), and immune complex deposition causes inflammation in kidneys, skin, joints, brain, and blood vessels
Most patients experience no adverse reactions, but in rare cases, individuals may report symptoms such as mild bloating, cramping, allergic reactions (rash or itching), or a metallic taste in the mouth
Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB
Hamanaka RB, Chandel NS