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A 2013 study by Prussick, Prussick, and Gutman outlines this further

Tao R, Tsai CJ, Jensen G, Eng C, Kopetz S , Overman MJ, Skibber JM, Rodriguez-Bigas M, Chang GJ, You YN, Bednarski BK, Minsky BD, Delclos ME, Koay E, Krishnan S, Crane CH, Das P

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Challenges in targeting glutamine metabolism for drug resistance Cancer cells in which glutamine metabolism is inhibited also undergo metabolic adaptation through multiple pathways to ensure their survival and proliferation, which is a serious challenge for tumor resistance