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In brief, berberine can reduce anti-apoptotic factors (Bax/bcl-2, caspase), autophagy related proteins (IL-3, Beclin, etc.), A pathology, and activate PI3K-AKT and other signaling pathways, and then produce neuroprotective effect (Figure 1)

Unpaired two-tailed Students t -tests were used for the comparisons between two groups

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GHK-Cu plays a significant role in skin regeneration, collagen synthesis, and DNA repair [3]