Different peptides interact with different cellular targets, making them valuable tools for investigating mechanisms related to metabolism, aging, regeneration, resilience, and cognitive function at a molecular level
26,27 Suggestive evidence of hemoglobin A1c-lowering being the cause of the reported worsening with GLP-1/GIP agonists can be derived by comparing the results of two recent retrospective cohort studies assessing retinopathy outcomes between subjects treated with GLP-1/GIP agonists and sodium-glucose cotransporter-2 (SGLT2) inhibitors
Esterhzy, D
Kypreos KE, Karavia EA, Constantinou C, Hatziri A, Kalogeropoulou C, Xepapadaki E, et al
Efficacy of esketamine nasal spray plus oral antidepressant treatment for relapse prevention in patients with treatment-resistant depression: a randomized clinical trial
Both are once-weekly injections from Eli Lilly, but retatrutide adds a third hormone receptor (glucagon) on top of the GLP-1 and GIP receptors that tirzepatide already targets