do glp 1 help with perimenopause Understanding GLP-1 Benefits for Symptoms HRT + GLP-1 for Perimenopause

The distinction matters because AOD-9604 preserves lean mass in animal models, and the mechanism of action suggests it does the same in humans

PubMed PMID 41966639, 2026

Bouman A, Heineman MJ, Faas MM

AMPK: AMP-activated protein kinase

Weight loss, which commonly occurs with tirzepatide therapy, can influence hormonal balance and thermoregulation, though evidence suggests that weight loss may actually improve vasomotor symptoms in some overweight postmenopausal women

Supplementation with NR is safe in mice and humans and has minimal toxicity, high bioavailability and high capacity to cross the blood-brain barrier (Trammell et al., 2016