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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, 101 thereby being roughly four times higher than those in normal rats

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T4 acts mainly as a prohormone, while T3 is the biologically active form that directly affects metabolism, including basal metabolic rate (BMR), lipid metabolism, thermogenesis and carbohydrate metabolism [3]

These findings demonstrate that aging is not a unilateral loss of stemness but rather a rewiring of stem cellniche interactions