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12 , 18 , 19 , 20 While there continues to be a robust area of research into drug treatment for MASLD, currently there is only 1 (recently) approved pharmacological therapy, resmetirom, a THR agonist

Your body builds tolerance to these receptor signals over time through a process called receptor desensitization, where your cells become less reactive to repeated exposure to the medication

This will allow scar tissue to develop at the injury site

Administration & Dosing Protocol Subcutaneous Injection (Standard): Loading: 10 mg/week (5 mg 2x, Mon/Thu)

Reduction of cardiovascular risk and improved estimated glomerular filtration rate by SGLT2 inhibitors, including dapagliflozin, is consistent across the class: an analysis of the placebo arm of EXSCEL

They also activate glutamine production by activating glutamine synthetase in perivenous hepatocytes and skeletal muscles