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It is a neurological response rather than a dermatological one, meaning the skin usually looks normal despite the discomfort

Pharmacology 337(12):118284 Balogun E, Hoque M, Gong P, Killeen E, Green CJ, Foresti R, Alam J, Motterlini R (2003) Curcumin activates the haem oxygenase-1 gene by regulating Nrf2 and the antioxidant-responsive element

Collagen fiber alignment, a key determinant of tendon tensile strength, appears to improve in BPC-157-treated tissue in animal models compared to untreated controls

Short-term use of topical nasal decongestant sprays (such as xylometazoline) may be an option for up to 7 days, but prolonged use can cause rebound congestion

2006 Nov;85(3):514-21

In addition, there are also possibilities to measure the level of substances of endogenous origin in the blood