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A similar restoration of capillary diameter towards normal size is seen on administering adenosine after coronary ischaemia 8 , probably also due to activation of ATP-sensitive K + channels 48 , and giving adenosine or the ATP-sensitive K + channel opener nicorandil improves outcome in human percutaneous coronary angioplasty by preventing no-reflow and thus improving ventricular function 49,50,51

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Conclusion Here, we identified a novel endogenous GLP-1-producing neural circuit that regulates cocaine-seeking behavior

Based on this finding, two incretin-based medications were developed: (1) DPP-4 inhibitors that increase the concentration of GLP-1 by inhibiting it [22], and (2) GLP-1RAs, which act directly on the GLP-1 receptor [23]

1) were observed in five negative-stain transmission electron microscopy images