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Patients with a history of pancreatitis face substantially higher recurrence risk and should discuss alternative treatments with their healthcare provider, as FDA labeling advises considering other therapies in this population

The FDA has taken notice

It is important to distinguish between perceived prevalence and clinically significant alopecia

PMID 26348896

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Hypoxia stabilizes HIF-1, which binds to the hypoxia response element (HRE) of the GPX4 promoter to inhibit GPX4 transcription (176)