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It is preferable to use combination therapies having complementary mechanisms of action that target different pathways addressing the multiple pathophysiologic abnormalities of T2DM [10,11,12]

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Important safety considerations include: Gastrointestinal symptoms at higher doses Individual tolerance variability Potential for hypoglycaemia when combined with insulin or sulphonylureas Limited long-term safety data in humans Limited data in children and adolescents Patients with diabetes taking glucose-lowering medications should exercise caution when introducing allulose

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References 1 AlmannaiM.AlfadhelM.El-HattabA

Whether you're considering Noom, Hims, or another provider, genetic insight can complement clinical evaluation