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found that lycopene pre-administration could modulate the TLR4/TRIF/NF-B pathway by significantly downregulating the expressions of TLR-4, TRIF, phosphorylated p65 proteins, which in turn suppresses the production of inflammatory cytokines IFN-, TNF-, IL-6, and IL-1 in colonic tissue, thereby reducing inflammation response in the context of UC(48)

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We anticipate that this approach in ALS will also positively impact the field of drug discovery for neurodegenerative disorders more broadly