Published studies have demonstrated accelerated wound healing in skin, hair follicles, gastrointestinal tract, bone tissue, and nerve tissue across multiple animal models
Engagement will be needed beyond Milestone A, through sequential updates to AoA and TIP, completion of a Technology Development Strategy (TDS) and a Test & Evaluation Strategy, as well as a Corrosion Prevention/Control Strategy (CPC) and a Life Cycle Sustainment Plan
307,308,309 Endothelial dysfunction is well recognized in DPN
This imbalance contributes to the increased permeability of the gut barrier, allowing the translocation of harmful bacterial products (such as lipopolysaccharides (LPS)) into the bloodstream, where they can activate the brains immune system and promote neuroinflammation, which is a major contributor to cognitive dysfunction (Guerville and Boudry, 2016
Detoxification of harmful lipid peroxides (Lipid-OOH) to their corresponding hydroxides (lipid-OH) by glutathione peroxidase 4 (GPX4) and glutathione-S-transferases (GST)
Carneiro-Filho, B.A., Lima, I.P.F., Araujo, D.H., Cavalcante, M.C., Carvalho, G.H.P., Brito, G.A.C., Lima, V., Montiero, S.M.N., Santos, F.N., Ribiero, R.A., Lima, A.A.M