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Tirzepatide Weight Loss Results In the landmark SURMOUNT-1 trial published in the New England Journal of Medicine , participants receiving the highest dose of tirzepatide (15 mg weekly) achieved an average reduction of approximately 20.9% of body weight over 72 weeks

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The study also revealed that tirzepatide induces specific miRNA expression, reversing epigenetic modifications caused by hyperglycemia and further promoting neuronal survival and differentiation