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Pharmacological reviews, 2016, 68(4), 9541013

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Subjects who show no response at 1.0mg likely have MC1R polymorphisms (common in individuals with red hair and Fitzpatrick Type I skin) that prevent receptor activation regardless of dose

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Tirzepatide favors the GLP-1R over the GIPR at mouse incretin receptors, whereas the opposite has been reported for the relative potency in human incretin receptors, for which tirzepatide activity is tilted towards the GIPR 5,16

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[PubMed: 1639946] 60

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