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People with compromised immune systems : Conditions like HIV, cancer treatments, or other immune system disorders can result in reduced glutathione levels, impacting the bodys ability to fight infections and heal

The molecular mechanism by which the PfK13 mutations confer artemisinin resistance in clinical isolates may involve multiple cellular and metabolic processes, including hemoglobin uptake and digestion, the unfolded protein stress response, mitochondrial functions, oxidative stress responses (including tRNA thiouridine modification reprogramming), and an enhanced DNA damage repair mechanism 3, 811, 1320